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Table 2 Time course of breast edema in scientific literature

From: Breast edema, from diagnosis to treatment: state of the art

Reference

Follow-up

Breast edema prevalence

Verbelen (own data, not published)

Prior to RT

52.5%

After termination of RT

63.8%

3 months after RT

55.3%

6 months after RT

57.1%

12 months after RT

47.5%

Adriaenssens 2012 [5]

0–3 months postoperative

93.3%

3–6 months postoperative

73.3%

6–12 months postoperative

82.4%

12–24 months postoperative

80.6%

24–60 months postoperative

65.4%

Berrang 2011 [29]

Prior to RT

32%

1 year after RT

16%

3 years after RT

6%

Vicini 2007 [15]

> 6 months after RT

32%

> 24 months after RT

22%

> 36 months after RT

0%

Young-Afat 2019 [38]

Baseline: prior to RT

12.0%

3 months after baseline

7.1%

6 months after baseline

12.4%

12 months after baseline

8.2%

18 months after baseline

5.5%

Olivotto 1996 [23]

Prior to RT

26.6%

3 year after RT

4.3%

5 years after RT

2.6%

Johansson 2015 [37]

Prior to RT

29%

2 weeks after RT

39%

3 months after RT

63%

6 months after RT

63%

12 months after RT

39%

24 months after RT

28%

Lam 2020 [39] (meta-analysis)

0–4 weeks after RT

26.2–47.1%

6 months – 10 years after RT

7.2–9.9%

  1. Most studies, apart from Adriaenssens et al. are based on the timing of RT to describe the time course of breast edema. Data concerning the amount of time post-operatively is not available
  2. Based upon the findings of Lam 2020 (a meta-analysis); about 7–10% of the patients will need treatment for breast edema provoked by BCS and radiotherapy
  3. RT radiation therapy